Rising incomes coupled with rapid advances in agricultural and food technologies have driven dramatic improvements in food production and global food and nutrition security over the past six decades. Growing concerns persist, however, over the sustainability of the global food system, driven by depletion of natural resources, deterioration of ecological systems, extreme weather events, and an epidemic of chronic diseases. More than 700 million people suffer from hunger, and approximately 2 billion are deficient in one or more micronutrients. Between 1 and 2 billion people suffer from water scarcity or lack access to safe drinking water. Meanwhile, the world remains largely dependent on fossil fuels as its predominant energy source, generating greenhouse gas emissions that drive climate change. The US, China, and India account for more than 40% of the world's population and collectively consume approximately 50% of global food, energy, water, and natural resources. As the largest developed and developing countries, respectively, these three nations have substantial and sustained impacts on the ability of the rest of the world to address existing and emerging challenges in the global food, energy, and water nexus. They share many common interests while facing distinct differences and challenges in meeting their needs for food, energy, water, and economic development. This interdisciplinary course is offered by Cornell University, with joint efforts from two leading agricultural universities in China (China Agriculture University and Nanjing Agricultural University) and the Tata Institute of Social Sciences (TISS), a premier institution offering undergraduate and graduate degrees in social sciences in India. The University of Arkansas joined the collaboration in Fall 2020, Hefei University of Technology (Hefei, China) joined in Fall 2022, and the University of Puerto Rico-Mayaguez joined in 2023. Plaksha University in India joined the collaboration this year.